If You want to use Virtual Scrolling/Paging then you can use RadGrid control.
When scrolling with the virtual scroll bar, RadGrid can use either standard postbacks or AJAX requests (when AJAX callbacks are enabled using RadAjaxManager, RadAjaxPanel, or MS UpdatePanel). By using AJAX callbacks, the overall behavior is smooth, with no flicker.
Follow this link-
http://www.telerik.com/help/aspnet-ajax/grid-virtual-scroll-paging.html