It is not necessary to use multiple IP addresses to send for multiple domains.
A reverse DNS (or PTR) record is only concerned with the 'reverse lookup zone', which is IP based. It is not concerned with the domain, nor is mail.
The important thing is that you have a reverse DNS record set up for the IP address. It is generally a good idea to use on of the primary domains you use to send mail. Set up a corresponding 'A' record for the domain in question that points to the IP address and you are in business.
You should set the SMTP virtual server to use the same as the reverse DNS record.
It is a common misconception, but the reverse DNS (or PTR) record does not need to match the domain of the mail messages you are sending. The important think is that you have a valid record.
Shaun