Dim gridRow As New DataGridViewRow
Dim gridCell As DataGridViewCell
'Add the Selected first combobox value to grid
gridCell = New DataGridViewTextBoxCell()
gridCell.Value = ComboBox1.Text
gridRow.Cells.Add(gridCell)
'Add the Selected second combobox value to grid
gridCell = New DataGridViewTextBoxCell()
gridCell.Value = ComboBox2.Text
gridRow.Cells.Add(gridCell)
' Add others also if required
DataGridView1.Rows.Add(gridRow)