1)How to secure the contents on the cd.
on setup, ask for Serial key and verifies it to web database means on-line verification. if serial key is found in database then add record for serial registration means now this serial key is in use.
2)How to make this application run only in one computer, so that a cd run on a computer once for the first time, cannot be used in another computer.
it is hard to get overcome this.
when you do verification to database and if it OK. then also do one procedure to store something values in client computer ( in registry, hard disk. ). so we can identify that user is valid to use this software.