These are programs deployed through the click-once application type. If you remember installing the .net framework for any of the products that you did a one-click install, then these are the files that are dumped by the installation.
If is better to remove the programs through the Add/Remove programs, and then delete the orphaned files. And also note that it is always advised to create a System Restore Point, and then do such actions. If something goes wrong, just restore the system to a previous state using the System Restore Wizard.
Hope this helps.